Forced to trade his valuable furs for a well-educated escaped slave, a rugged trapper vows to recover the pelts from the Indians and later the renegades that killed them.
At a Mexican ranch, fugitive O'Malley and pursuing Sheriff Stribling agree to help rancher Breckenridge drive his herd into Texas where Stribling could legally arrest O'Malley, but Breckenridge's wife complicates things.
An American bartender and his prostitute girlfriend go on a road trip through the Mexican underworld to collect a $1 million bounty on the head of a dead gigolo.
While attending the birth of Isabel, the wife of foreigner Felipe, Mama Santos predicts that "something terrible is going to happen in the town." From this omen, calamities will torment the locals.